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Ivermectin is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis). Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This syndrome has been seen very rarely following the use of ivermectin. However, since the ivermectin effect is not immediate, care must be taken to prevent reinfestation from exposure to untreated animals or contaminated facilities. Free ivermectin may adversely affect fish and certain aquatic organisms. However, data are limited and further study is required to define the role of ivermectin for this condition.

Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. Ivermectin: novel systemic antiparasitic agent. Efficacy and tolerance of ivermectin in human onchocerciasis. Controlled trial and dose-finding study of ivermectin for treatment of onchocerciasis.

Side-effects of ivermectin in treatment of onchocerciasis. The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution. Ivermectin: a long-acting microfilaricidal agent. A controlled trial of ivermectin and diethylcarbamazine in lymphatic filariasis. Pregnancy outcome after inadvertent ivermectin treatment during community-based distribution. Free ivermectin may adversely affect fish and certain water born organisms on which they feed. Unlike previous treatments, which had serious – sometimes fatal – side effects, ivermectin is safe and can be used on a wide scale.

Ask your health care provider if ivermectin may interact with other medicines that you take. If you are or will be breast-feeding while you use ivermectin, check with your doctor. This is only a brief summary of general information about ivermectin. The drug of choice is ivermectin (which has been successfully used for the treatment of onchocerciasis), in combination with albendazole, an anti-helminthic. If they had had a child and the infants were alive, then they were asked to bring the child on a specific date for examination and given a card with the name of the child and mother as a reminder and for identification of appropriate children by the physicians. Oral hydration, recumbency, intravenous normal saline, and/or parenteral corticosteroids have been used to treat postural hypotension.