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Using ethanol with ivermectin can increase the blood levels or add to the side effects of ivermectin. Because of the possibility for adverse reactions in nursing infants from ivermectin, a choice should be made whether to stop nursing or to stop use of this medication. Although ivermectin is generally well tolerated by patients, it can cause side effects such as fever, dizziness, headache, and rash. Some people might consider this to be a con of using ivermectin since they have to visit their doctors in order to gain access to this treatment.
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The dose for ivermectin varies from species to species and also depends on the intent of treatment. In fact, abamectin appears to be marginally more toxic than ivermectin in all these studies. The main signs of toxicity in animals given ivermectin orally or by subcutaneous injection were depression and ataxia. There were no significant differences in the number of live offspring produced by ivermectin-treated animals when compared with controls. Despite the extremely wide use of ivermectin, there is no evidence of significant incidences of adverse effects on reproductive performance in treated animals and the very limited data on reproductive toxicity in humans indicate that ivermectin does not increase the incidence of birth defects.
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Tolerance of single high-dose ivermectin for treatment of lymphatic filariasis. Efficacy and tolerance of ivermectin in human onchocerciasis. Ocular findings in a double-blind study of ivermectin versus diethylcarbamazine versus placebo in the treatment of onchocerciasis. Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: combined results from eight community trials. Lack of adverse reactions in ivermectin treatment of onchocerciasis. A prospective study in high risk subjects of electrocardiographic changes with ivermectin.
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Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. Prolongation of prothrombin time with ivermectin. Community-based treatment of onchocerciasis with ivermectin: acceptability and early adverse reactions. Pregnancy outcome after inadvertant ivermectin treatment during community-based distribution. Community-based treatment of onchocerciasis with ivermectin: safety, efficacy, and acceptability of yearly treatment. The ocular effects of ivermectin and diethylcarbamazine. Ivermectin treatment of patients with severe ocular onchocerciasis.
However, since the ivermectin effect is not immediate, care must be taken to prevent reinfestation from exposure to untreated animals or contaminated facilities. Free ivermectin may adversely affect fish and certain aquatic organisms. However, data are limited and further study is required to define the role of ivermectin for this condition. Ivermectin: novel systemic antiparasitic agent. Controlled trial and dose-finding study of ivermectin for treatment of onchocerciasis.
Side-effects of ivermectin in treatment of onchocerciasis. The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution. Ivermectin: a long-acting microfilaricidal agent. A controlled trial of ivermectin and diethylcarbamazine in lymphatic filariasis.
Pregnancy outcome after inadvertent ivermectin treatment during community-based distribution. These reports found that the risk of fetal damage in pregnant women treated with ivermectin was no greater than control. Ivermectin and related drugs are among the most effective of these. Therefore, ivermectin does not appear to be selectively fetotoxic to the developing fetus.
This is likely the result of severe hypoalbuminemia since ivermectin is highly protein bound. Satety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. Comparative pharmacokinetics of ivermectin after its subcutaneous administration in healthy sheep and sheep infected with mange. Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. Comparative pharmacokinetics of doramectin and ivermectin in cattle. Ivermectin in goat plasma and milk after subcutaneous injection.